What genetic condition is associated with cleft lip and palate?

Cleft lip and palate are structural conditions that can occur due to various genetic and environmental factors. Pierre Robin sequence is a genetic condition that is specifically notable for its association with craniofacial abnormalities, including cleft lip and palate. This sequence typically involves a combination of a smaller than normal jaw (micrognathia), a cleft palate, and often a tongue that is positioned further back in the throat, which can lead to breathing difficulties.

This genetic condition often occurs as part of other syndromes but is uniquely recognized for the development of cleft lip and palate as a direct feature. Conditions such as Down syndrome and Fragile X syndrome are associated with various cognitive and physical challenges but do not directly correlate with the specific presence of cleft lip and palate. Autism Spectrum Disorder, while a developmental disorder, does not have a direct link to craniofacial malformations like cleft lip and palate. Thus, Pierre Robin sequence stands out as the condition most directly connected to these particular craniofacial anomalies.